My Test Results: Cholesterol and APOE

**Disclaimer: I am not an expert and this is not intended as medical advice; it is my personal experiences and research. I feel very strongly that while there may be some changes that everyone could benefit from, there is no "one size fits all" when it comes to health.**

I found out that my cholesterol levels were not ideal when I found out about my PCOS. The doctor gave me the standard advice that you think of with cholesterol. In fact, out of curiosity, I googled how to manage high cholesterol without medication. Here are the recommendations that the Mayo Clinic gives:

1. Lose weight.
2. Eat heart-healthy foods.
• Choose healthier fats. "Saturated fats, found in red meat and dairy products, raise your total cholesterol and low-density lipoprotein (LDL) cholesterol, the "bad" cholesterol... choose leaner cuts of meat, low-fat dairy and monounsaturated fats--found in olive, peanut, and canola oils..."
• Eliminate trans fats.
• Limit the cholesterol in your food.
• Select whole grains.
• Stock up on fruits and vegetables.
• Eat foods rich in omega-3 fatty acids. 
3. Exercise on most days of the week. "...exercise can reduce cholesterol...better yet, moderate physical activity can help raise...HDL." 

For the most part, I was doing all of those things; so I continued life without changing much. I think I was partially in denial because of my already "healthy" diet and lifestyle. And at the time, the PCOS diagnosis was what I focused on. But the doctor told me that she would recommend medication to manage my cholesterol if I could not manage it without medication. A few years go by. In October of 2013, I had a few labs done for the wellness incentive program at work. I was reminded again of my cholesterol, and it was a bit of a wake up call. But really, it was still fairly low on my list of priorities. A year later, I had the labs done again for the incentive program. After almost a year on the Paleo diet, my numbers had barely changed. I was very discouraged. This doctor also mentioned medication, but in the context of not wanting to prescribe medication if we would be trying to start a family anytime soon. But I was at a loss for what to do. Paleo had let me down in this area. Was my only choice to have oatmeal or cheerios for breakfast and never eat bacon or egg yolks again?

Before I share my results, there are a few things that I'd like to point out about cholesterol:

• According to the American Heart Association, cholesterol is one of the major controllable risk factors for coronary heart disease, heart attack, and stroke. 
• BUT, cholesterol itself isn't bad. Your body makes all of the cholesterol you need and circulates it through your blood. But cholesterol also exists in animal products. 
• Your body responds to saturated and trans fats by producing more cholesterol. 
• Cholesterol is transported through your blood by carriers calls lipoproteins. The two types of lipoproteins are low-density, or LDL, and high-density, or HDL. 
• LDL cholesterol is considered the "bad" cholesterol because it contributes to plague. It is plaque that can clog arteries and cause heart attack or stroke.
• HDL is considered the "good" cholesterol. It helps remove LDL from the arteries. Experts believe that HDL carries LDL away from the arteries and back to the liver, where it is broken down and passed from the body. A healthy level of HDL may also protect against heart attack and stroke, while low levels have been shown to increase the risk of heart disease. 
• Your total cholesterol is determined by the total of your LDL, HDL, and one fifth of your triglyceride level. 
• Triglycerides are another type of fat that is used to store excess energy from your diet. 

My tests at Vine confirmed what I already knew. But this set of labs, Boston Heart, gave me even more insight and information than total cholesterol, LDL, HDL, and triglycerides. And from my research, it seems that other markers can be more even more accurate for measuring your risk. This panel is several pages long, but here is one of the relevant sections.

Regardless of whether you know what any of these things mean (believe me, I've done lots of googling), that is a lot of red and yellow and very little green.

Here is where the blessing of testing and guidance from a medical professional who can customize your care comes in. From my genetic testing, I discovered that I have the E3/E4 variation of the ApoE gene. This is a gene that everyone has (E3/E3 is the neutral and most common genotype, expressed in 60% of the population), but it can mean very different things depending on which variation you have.

Clearly we will be ignoring the advice about medication at this point.

This makes such a big difference in my understanding of why I have high cholesterol in spite of my healthy lifestyle and even in spite of my Paleo diet. Without knowing about this gene variation, I honestly would have been at a loss for what to do. Most likely I would have had to choose between cholesterol medication and developing cardiovascular disease. This video gives an excellent, concise explanation about ApoE, even in the context of Paleo and why there is no "one size fits all" in treating disease.

Here is another post about ApoE that I found helpful, as it also gives some more specific recommendations based on each variation.

In my research, I found the book The Perfect Gene Diet (also known as The Apo E Gene Diet). Here is a video from the author, Pamela McDonald, and this an overview of some of the information in the book.

This book has a wealth of information not only about what the Apo E gene and its variations are and what they mean, but what to do once you know which variation you have. There is a very good chance that I have left lots of holes in trying to explain this gene and how it affects/can affect me, or maybe I'm repeating myself and this is overkill, but here are a few summary points:

• First, what Apo E means. McDonald explains:

"Our body has evolved a...method of moving fats around inside it...Apo is short for apolipoprotein. It has the letter "E" because it's one of a whole series of apolioproteins--A, B,C, etc...In a larger sense, the Apo E gene is involved in the energy system of the body...The Apo E gene can provide good health if the body is given the correct foods and other gene-supportive environment factors for its Apo E type. On the other hand, the Apo E gene can impair good health if the body is given the wrong foods and other gene-unsupportive environmental situations. The Apo E gene is the key to making the right match...to determine the environment that will best support...a safe, optimal level of cholesterol in your system."

• "The Apo E 4s have the greatest difficulty clearing fats from their bodies, especially the more complex inflammatory fats, and must significantly limit saturated and trans fats."
• My variation does put me at increased risk for cardiovascular disease and Alzheimer's, but "It is important to realize that the presence of Apo E 4 does not cause cardiovascular disease and other conditions like Alzheimer's disease. Nor does it necessarily mean that the person will develop such diseases. What is important is matching your diet and lifestyle to the needs of your genes." 
• "Of the three kinds of Apo E genes, the 4s...are the most sensitive to high-fat diet and need more carbohydrates than the other types."
• Apo E 4 does better with plant-based sources of protein and fat (versus animal). 
• "Apo E 4 has a very limited to no ability at all to clear toxic substances absorbed from our diet.
• It has been proven repeatedly that individuals with any of the Apo E 4 combinations will respond better to dietary changes than the other genotypes..."

I'm sure I've just scratched the surface of what there is to learn about this. Coming up: what I'm doing about it and an update on how I'm doing after some follow-up labs.

Test Results: MTHFR

The genetic testing is definitely an area that I didn't think about before I started at Vine, but the results are so eye opening and make so much sense to me. The first one of the gene's that I am going to talk about is MTHFR. This gene was not new to me. In fact, when the doctor told me I was positive, I laughed because I was somewhat suspicious. It turns out that I'm pretty good at self-diagnosis, and I'm not just a huge hypochondriac. :) Because I am interested in health and nutrition and follow a lot of health-related blogs and bloggers I had heard about MTHFR before, but I didn't do any research until I saw several posts from Hayley from Primal Palate on Instagram that she was navigating a MTHFR diagnosis. Shortly after I received my test results, she posted this update and I identified with so many of her experiences. Yet again, I am reminded of how grateful I am that I am getting answers that so clearly explain the physical, mental, and emotional problems that I have had over the last 10+ years.

I feel like I need to say this with every post, but I encourage you to do your own research and look at the links that I have provided if you want more information. I am sharing some of the things I have learned from researching, but I am mostly focusing on my experiences and what I am doing to address these results. If you identify with any of these things I would encourage you to look into getting tested, if possible.

Two of the genetic tests were positive: MTHFR and ApoE.

Other test results:

The MTHFR gene mutation is not uncommon; experts say that half the population is positive. Dr. Antoine said that the majority (80 or 90%) of her patients are positive. So it could very well be the underlying cause of a lot of health concerns.

Here are some of the resources that I have used to learn about MTHFR:

• mthfr.net
• MTHFR Genetic Defect - What It Is and How It Can Affect You
• Methylation Problems and Gene Mutations (Listen to the podcast if you have a chance.)
• What Do You Do If You Have MTHFR
• This Is the Way Your Life Changes

Coming up: what I'm doing about it.

Test Results and Changes: Intestinal Permeability (Leaky Gut)

I am going to talk about a few of the things that showed up in my test results individually so that I can address the actual results, what those mean, and what I am doing about it. The first thing that I want to address is leaky gut. 

You can find lots of info about leaky gut and how to treat it, but I especially like my beloved Kresser's post (I also like this post by Dr. Axe). Chris Kresser gives the following explanation:

"When the intestinal barrier becomes permeable (i.e. “leaky gut syndrome”), large protein molecules escape into the bloodstream. Since these proteins don’t belong outside of the gut, the body mounts an immune response and attacks them."

Take a look at those two posts to learn more about leaky gut and what to do about it; they say things better than I ever can. But I'm going to use this post to show you my test results as well as the supplements and lifestyle changes that I am using to address my leaky gut. 

Looking at the the following image, you can see that my body was working overtime trying to deal with all of the invaders that were a result of my leaky gut.

What am I doing about it?
Different articles may have differences in the specific recommendations, but this is the program that Dr. Antoine uses:

The 6 "R" Gut Healing Program

• Remove - food allergies and sensitivities, food toxins, abnormal bacteria, etc. 
• Replace - with healthy nutrients 
• Restore - the lining of the GI tract (glutamine, omega-3 fats, vitamin D, etc.)
• Reinoculate - with probiotics 
• Rebalance - with stress reduction, prayer, meditation, breathing exercises, etc. 
• Rotate - the foods you are eating to receive a variety of nutrients (and avoid harmful affects of having too much of a certain food)

Remove:

1. Food allergies and sensitivities 

  

Above is the list of everything that was included in the food panel. The first two images are from the IgG. An IgG measures your immune response to foods. If the food is black, there was no response; if the food is red there was a response. The asterisks (and numbers 1-3) indicate the level of sensitivity. The fact that there are a lot of red foods (as well as other test results) point to intestinal permeability (or leaky gut), because a person should not have an immune response to food. The third image is the IgE (or allergy) test, and you can see that I have a true allergy to cow's milk. My scores for egg white and wheat were also close to an allergy score, so that could be a sign that those will remain as sensitivities. We'll see.

The IgG identifies the list of things that have to come out of the diet. Any food on the list that is a 2 or 3 come out until we test again (around 6 months from when I received my test results, which falls in August). Any food that is a 1 should be kept out for at least two months but can be introduced and enjoyed no more than once a week. When introducing a food, you have a serving with each meal for one day, and you have successfully reintroduced the food if you do not have any symptoms within three days. The only food that I have tested and reintroduced so far is beef. Once the gut is healed, a response should indicate a true sensitivity. There is a good chance that if I am diligent about healing my gut and excluding problematical foods from my diet, I should be able to reintroduce some of the foods that showed up as sensitivities on this test.

2. Food Toxins
It is important to eat unprocessed, non-GMO, organic foods. The Vine diet also excludes shellfish and pork (see Why You Should Avoid Pork) because of the toxins in the meat. I exclusively buy organic produce that is on the the dirty dozen list, but I am a little more lenient for things that are on the clean fifteen for the sake of our budget. With meat, I try to buy grass-fed beef, free range poultry, and wild-caught fish as much as possible. From research that I've done, most toxins are in the animal's fat. So if you have to buy conventional meat, it's better to stick to lean cuts. I am also trying to limit my animal fat consumption and my toxic exposure for other reasons that I'll address in separate posts.

3. Abnormal Bacteria

My stool sample did show a lack of beneficial bacteria (which I will address in the Reinoculate section) as well as an overgrowth of "additional" bacteria. The additional bacteria is not necessarily harmful, but it can become harmful if you have too much bacteria that is nonessential or beneficial. I also have a slight overgrowth of candida.

This is where my first supplement comes in. I am taking a supplement to kill bacterial overgrowth:

 

The ingredients that fit in with this category are:  

• Magnesium Caprylate (to treat Candida) 
• Berberine Sulfate (to treat Candida)
• Grapefruit Extract (for yeast overgrowth. I also found that there is research around grapefruit's ability to lower cholesterol and treat headaches, stress, and depression, as well as other things.) 

Restore
Other R's can begin to restore the gut lining, but I am also taking a supplements to aid the process. These supplements may have other benefits, and if so I will touch on those in the corresponding post.

The optimal levels are the middle numbers, 30-100. In January I was at 20. 

Read more here.

Omega 3 fats reduce inflammation. 

I use protein powder as a meal replacement for breakfast if I need something to take on the go. 

The protein powder also contains these GI benefits. From Dr. Axe's post, linked above: "Glutamine is an essential amino acid that is anti-inflammatory and necessary for the growth and repair of your intestinal lining.  L-glutamine acts a protector and coats your cell walls, acting as a repellent to irritants."

Reinoculate 
This one is pretty straight forward: it's important to introduce beneficial bacteria. In this case, I'm doing that with probiotics. Diversity is good, so getting bacteria from other sources is a bonus. I cannot have dairy, so sources like yogurt or kefir are out. But I love things like fermented vegetables and kombucha, and I try to have a serving several times a week in addition to my daily probiotic.

I have made my own sour kraut and I love it, but Bubby's is an awesome option that you can pick up in the store. They also have a relish that's great. 

Rebalance 
I will talk more about stress reduction in another post. But one thing I will address here is  removing stress by eating as often and as much as your body needs. Because my hormonal imbalance affected my appetite, I was consuming very few calories in a day because I just wasn't hungry. I would skip meals and eat the majority of my calories in the evening, at dinner; but that didn't come close to meeting my daily calorie need. I put my body under unnecessary stress when I didn't eat enough or as often as I should. I haven't missed breakfast since my first appointment in January, and I eat at least three meals a day, with snacks between meals if I need them. I find that I really need a snack in the afternoon between lunch and dinner, especially on days that I commute to work, because we usually won't sit down to dinner until 7:00 or later.

Rotate
Not much to say about this one. :) Eat a variety of foods. I try to mix up our proteins and veggies every week. It can help to simply buy whatever is on sale or in season that week. Having habits help me, so I will just keep it simple. For example, I have a big salad for lunch almost every day, but I switch out the kinds of greens and toppings/additions that I use every day and try I try to buy different things to choose from each week. 

My Wellness Journey, Part I: Background Story

I started this post almost a year ago. Lots of things have changed since I started drafting this story. I'm going to share a little (or a lot) bit of background about where I was and how I got to where I am now. This is going to get personal, but I want to be completely transparent so that my memories don't exclude the embarrassing stuff and so you have a complete picture.

I added the following preface before tweaking my diet, when this was going to explain my experience with Paleo. I decided to leave it, and it is still mostly true. Also, how ironic is the line about ice cream? (insert sob here)

* I don't necessarily like labeling myself as Paleo because so many people have different definitions of what that means, and it seems to create an expectation of perfectly sticking to a list of "good" and avoiding "bad" foods. I prefer a little more balance and moderation in my life. But it usually gives people a frame of reference and something to google. All I know is that I feel best when I eat this way, but no way am I giving up ice cream for the rest of my life just because it isn't Paleo. Also, as I use the word diet throughout this post, I mean diet as "what you eat" not "what you do when you want to lose weight." I did lose weight (only extra weight that I had gained), and I was hoping that eating this way would get me back to a weight that is more comfortable for me and a better weight for my body. However, this lifestyle change is 100% about being healthy and not in the least about being skinny. I would happily be at a higher weight if it meant that my health issues were resolved.

In general, I think that I had a fairly healthy childhood (even though I did have lots of chronic things like ear infections, strep throat, and croup), but I first started to notice things were off when I was 16. The first obvious thing was my cycle. I had been very regular since getting my first period at 12, but it started to become the norm to miss two, three, or four months. I also started to have constant breakouts on my shoulders, back, and chest. My PMS and menstrual symptoms got worse and worse, with painful cramping that would wake me up in the middle of the night, and I had my first "ovulatory" pains (that I always worried pointed to a ruptured cyst) sitting in study hall. The pains were different than what I experienced with other cramping. The pain would only last for 20-30 minutes, but it was painful enough that I could not stand up straight and my abdomen would be tender for a few days after. I can clearly remember where I was almost every time I experienced the pains: in class in high school, in the bathroom at a restaurant for my birthday dinner, in my dorm room, squated in the kitchen at a friend's house, etc. And I started to have a lot of issues with anxiety, mood swings, and depression. This continued well into college, and college also brought about some new health issues: chronic tension/muscle headaches, reflux (though I think I was showing signs for that earlier), and mysterious stomach pains. I didn't feel like myself for most of my college years, and I don't like a lot of the things that I see when I look back at that girl. I was tired all of the time. It was a struggle every day to get out of bed, even if I had had plenty of sleep the night before, and I often needed naps in the afternoon to get through the rest of the day. It was like I was in a fog, and I couldn't focus clearly on anything. I had a hard time connecting to the people around me, my anxiety made the demands of college and social interaction more and more overwhelming, and I felt completely lost most of the time.

Any time I had asked a medical professional about my irregular cycles, they brushed me off. It wasn't until Ryan asked one of his fellow counselors at Spring Hill about it and she encouraged me to go to the doctor that I decided to make my first gynecologist appointment. At my first appointment (in October of 2011), the doctor ordered several tests and gave me progesterone in the hopes that it would force a bleed (which it did). After a few weeks, I went back to my follow-up appointment. It was there that I received my PCOS (Polycystic Ovarian Syndrome)  diagnosis. I have learned so much about PCOS since that day, and although the diagnosis was scary and such an unknown, I still feel so grateful to have been diagnosed when I was. The doctor's recommendation was to use the Pill to manage my symptoms and regulate my period. But it also had it's own set of sideffects and repercussions. A few of the benefits, other than regulating my cycles, included clearing my skin and making it so I had to shave way less often (a weird but awesome thing that I miss very much), and lots of emotional things that I didn't recognize until I looked back (or until I went off the Pill and my symptoms started coming back). It really started to feel like the cloud was lifting, and I feel like my senior year at Cedarville, including that following summer and extra semester, was a taste of what my whole experience could have been like. I was able to focus on my studies, I was thriving in my jobs, I became a morning person, and I felt happy and hopeful about the future. But...

Soon after our our wedding, other symptoms flared and continued to get worse. The knots in my neck and shoulders and headaches were constant and painful. The reflux also became almost constant. There was an achy feeling in my throat most of the time, and sometimes it was bad enough that it made it hard for me to sleep. I made an appointment with an ENT to make sure that the reflux wasn't doing serious damage, and the doctor's only recommendation was to use a proton pump inhibitor. Also, My weight had steadily climbed to the point where I felt like a stranger in my body. My clothes were tight and uncomfortable, and I just generally didn't feel good. I was trying to be active and to be aware of what I was eating. That may have prevented me from gaining more, but I didn't lose a single pound. No matter what I did. I felt so frustrated, discouraged, and (while this might be a bit dramatic) betrayed by my body. I couldn't think of anything that I had changed enough to make such a drastic difference in my health. And saw myself as a "healthy" person, especially when I compared myself to a lot of the people around me, with eating a balanced diet and avoiding most processed foods. I didn't even realize how much I had gained until I stood on a scale in the doctor's office and heard a number that told me I had gained almost 20 pounds in the four months since our wedding. Lastly, my low (or nearly nonexistent) libido also started to take its tole on our brand new marriage. After a year of this, I knew something needed to change.

In December of 2013, after coming across several Paleo articles and blogs, I decided to try this lifestyle for myself. I had read about gluten and PCOS after my diagnosis and had read about the Whole30 experience of several bloggers that I followed, and it was Chris Kresser's guide about GERD that tipped the scales.

I committed right away, and I really stuck to Paleo guidelines 90% or more of the time. My headaches and reflux went away (except when I ate something I shouldn't) and my stomach aches (mostly) went away. I went off the pill and the weight steadily came off, except for the last five pounds. I wonder if the people in my life thought this was just another phase, but it wasn't. Eating and adopting other lifestyle changes fit in seamlessly with the kind of natural, holistic direction that I was moving toward.  And I was getting better! I had made a lot of changes and had seen quite a bit of improvement. But... a lot of my PCOS symptoms had gradually come back after going off the Pill. I had no appetite, my skin was terrible again, and my cycles almost completely went away (went off the pill in February of 2014, was a little late in March, skipped April, and then went from May to October, and then from October to February). I was feeling more and more anxious and overwhelmed and just exhausted physically, mentally, and emotionally.

Ryan and I decided before our wedding that we would wait to start trying for a family for at least two years. As I saw that milestone approaching combined with all of the issues that I had been experiencing, I really started to worry about feeling ready (as ready as possible) to start trying. I was constantly reading and researching and trying different things, but I felt a little bit like I was just chasing my tail. And I kept finding story after story of women who looked like me, who had been diagnosed with PCOS, and who were struggling to conceive or to carry a baby to term. I was starting to mourn over this broken body of mine and the heartbreaks it could cause, even though we had yet to start trying, and it terrified me. Finally, there were two things that told me I needed help. The first thing was my conversation with my gynecologist (the one I had been seeing since moving to Indiana). I told her about my cycles and my decision to go off the pill, and I asked her if there was anything that I could do to start preparing for pregnancy. Her response still makes my blood boil and also makes me incredibly sad. She looked me in the eye, shrugged, and told me no. She essentially said that not everyone's body works the way it should, that the definition of infertility was trying for a year without success, and that if we found ourselves in that situation then we would go from there and come up with a plan. She had no other advice other than to put me on a prenatal. I walked out of there extremely determined to prove her wrong. Second was my cholesterol. In October, I had blood work done for Ontario's wellness incentive program. I was excited to see how my numbers had improved after making so many changes to my diet. I was shocked when my numbers had barely changed. My bad cholesterol was still too high and my good cholesterol was too low.

Ryan and I talked and agreed that it was time to get some medical advice. I did some research and found Vine Healthcare and Dr. Ellen Antoine on the Primal Docs website. I felt so much hope as I read the information on the website, and I knew this was an investment that I wanted to make. I made a deal with Ryan that we would save our HSA money for few more months and wait until the first of the year.

My first appointment at Vine was on January 20th, 2015. In preparation, I had filled out a detailed medical and family history and symptom analysis. Dr. Antoine and I spent an hour together going over everything, and then I met with the nutritionist to discuss the "short term plan" that I would follow until we were able to go over my test results. I also had blood work done--15+ (I lost count) vials of blood. I left with my plan and a bag of supplements, and I felt both overwhelmed at the journey ahead but also hopeful and thankful to have this opportunity to get answers.

My Vine diet was fairly close to what I had already been following, with a few differences: no beef, pork, or shellfish; no eggs; legumes were allowed; only one piece of fruit per day. And there were no exceptions allowed. I texted Chris and joked about how I used to think the Whole30 was hard. And as far as the number of things that I could eat, it was harder, but emotionally and mentally this was so much easier. And that feeling hasn't really gone away. The only times that I really wanted things I couldn't have was when I had to watch everyone else eat it, and I think I will always have a hard time with feeling high maintenance because of all of the things that I don't or can't eat. It can also be very difficult to eat out and leave feeling full, since my diet is so far away from the standard American diet (SAD).

I went for my second appointment on February 26. I had been encouraged to bring Ryan with me, and I was glad to have him there to hear all of the results. Right away the doctor went over all of the results with us. Here is an overview of everything they found:

• Allergic to cow's milk
• Numerous IgC (delayed hypersensitivity reactions) to lots of foods, which indicates intestinal permeability (or leaky gut). Grains, gluten, nuts, and seeds (in addition to diary) show a pattern for negative response. 
• Stool analysis showed lack of beneficial bacteria and overgrowth of additional bacteria (including candida). 
• Immune level slgA is very high indicating that the immune system is working hard. (Normal level is 50-200 and mine was almost 900)
• High need for vitamin C and alpha lipoic acid
• High need for B1 and B6
• High need for zinc
• Moderate need for B3, B7, B9, and B12
• Moderate need for magnesium
• Moderate need for omega-3 fats
• Lysine deficiency 
• High need for glutathione 
• Moderate need for plant based antioxidants
• High need for methylation 
• Moderate mitochondrial dysfunction and toxic exposure
• CoQ10 is high
• Borderline low on most elemental minerals
• High bad cholesterol (LDL) at 165 (should be less than  100) 
• Too low good cholesterol (HDL) at 55 (should be at least 60)
• LDL-P much too high at 2000 (should be less than 1000)w
• Lp(a) indicates increased risk for stroke and cardiovascular event
• Lp-PLA is higher than ideal and increases risk for stroke
• Liver enzyme is elevated at 44
• Methylation genetic mutations (MTHFR) with both copies of both genes mutated
• MTHFR Gene Mutations and Disease
  What do I do if I have MTHFR?
• ApoE3/E4 gene places me at increased risk for cardiovascular disease and Alzheimer's 
• High Cholesterol and the APOE Gene
• APOE Gene
• Vitamin D is low at 20 (should be 60-80)
• Testerone is slightly elevated at 50 (ideally 30s-40s)
• Progesterone level is lower than it should be

Whew. 

I'm now on the "long term plan," that will last about 6 months. This involves continuing the strict diet and lifestyle that I began in January, with the removal of lots of other foods and the addition of lots of other supplements. I'm already getting tired of being so limited in what I can eat, and it takes work to keep track of all of the other supplements and lifestyle things that I should be doing each day. And no babies until I get the all-clear from my doctor. Meh. One day at a time. Some of the supplements will go away, and some foods will hopefully come back, but a lot of the changes I'm making are going to have to be lifelong if I want to maintain the health I will have gained.

As far as how I'm feeling now, I still know I have a long way to go, but here are the things I have noticed:

• My skin was one of the first signs of improvement. The acne that came back after going off the Pill has vanished. It's amazing to me to see my skin so clear, with no sign of the acne that was there only a few months ago. I'm very happy to see it go.
• The last few pounds that stuck around are gone. I'm being more intentional about exercise, so my weight will most likely continue to fluctuate as I hopefully lose fat and build muscle mass. 
• I'm sleeping more soundly and without waking much. But I still need to work on getting more sleep. 
• I have noticed my anxiety level being much, much better in certain situations. For example, I noticed that I barely reacted to the traffic when I traveled to and from Ohio last month. Certain areas used to leave me shaking and in a near-panic. 
• My hair is growing!! Slowly but surely, my hair is growing, and I have baby hairs sticking up all over my head to show for it. 
• My stomach aches had significantly decreased after adopting Paleo, and they have become increasingly rare. I can only think of two times I experienced them since January. So I'm not sure if they are actually always caused by WHAT I am eating, but maybe how or when? 

I occasionally get discouraged that I don't feel AMAZING (how silly am I?), but I know this is a process. Dr. Antoine said that she always tells her patients that for every year that they have been sick, they should expect to take 2 months to recover. And I'm in for the long haul. 

I decided to go to Vine when I felt that I had done all that I could do on my own and that I needed answers. I wanted to be as healthy as I could be before starting a family, and I also wanted to minimize our risk of infertility or miscarriage. The tests uncovered so much more than I expected. This is definitely turning into a lesson in patience and trust. I still don't have all of the answers, but I do feel very blessed to have a better understanding of what is going on inside of me and to be able to start doing something about it. I continue to pray for healing and that God would give me and my doctors wisdom as we navigate all these things. His is faithful. To Him be the glory.

I'm going to leave it at that for now. I would love to hear any questions that you have. I have often felt alone in this journey, so I would be happy to share with anyone who is interested. :)

I do want to end with something that I read on MTHFR.net. This is how I'm choosing to feel about all of my results:

"Let me say one thing and hear me clearly:
Knowing if you or a loved one has the MTHFR mutation is a blessing. It is not bad news. It is very positive.
Why??
Because knowing you have it means you can do something about it!
Let’s get to doing something about it."